Mitochondrial DNA instability in mammalian cells
نویسندگان
چکیده
منابع مشابه
Mitochondrial transcription in mammalian cells.
As a consequence of recent discoveries of intimate involvement of mitochondria with key cellular processes, there has been a resurgence of interest in all aspects of mitochondrial biology, including the intricate mechanisms of mitochondrial DNA maintenance and expression. Despite four decades of research, there remains a lot to be learned about the processes that enable transcription of genetic...
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Rev3L encodes the catalytic subunit of DNA polymerase Z (pol Z) in mammalian cells. In yeast, pol Z helps cells bypass sites of DNA damage that can block replication enzymes. Targeted disruption of the mouse Rev3L gene causes lethality midway through embryonic gestation, and Rev3L / mouse embryonic fibroblasts (MEFs) remain in a quiescent state in culture. This suggests that pol Z may be necess...
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ژورنال
عنوان ژورنال: Antioxidants & Redox Signaling
سال: 2021
ISSN: 1523-0864,1557-7716
DOI: 10.1089/ars.2021.0091